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Increased expression of ATP‐binding cassette transporters in enfortumab vedotin‐resistant urothelial cancer

Authors :
Mariko Kotono
Toshiki Kijima
Atsuko Takada‐Owada
Naoya Okubo
Ryo Kurashina
Hidetoshi Kokubun
Toshitaka Uematsu
Kohei Takei
Kazuyuki Ishida
Takao Kamai
Source :
IJU Case Reports, Vol 7, Iss 2, Pp 173-176 (2024)
Publication Year :
2024
Publisher :
Wiley, 2024.

Abstract

Introduction In addition to reduced nectin‐4 expression, the upregulation of ATP‐binding cassette transporters has been suggested as a potential mechanism of resistance to enfortumab vedotin. Case presentation A 76‐year‐old man previously treated with platinum‐containing chemotherapy and pembrolizumab for metastatic bladder cancer was administered enfortumab vedotin because of disease progression. Subsequently, metastasectomy was performed for oligometastatic lesions (in the lung and adrenal gland) that exhibited growth during enfortumab vedotin therapy. Immunostaining analysis revealed decreased nectin‐4 expression and elevated MDR1, MRP1, and BCRP expression in the metastatic lesions. Conclusion Decreased nectin‐4 expression and increased ATP‐binding cassette transporter expression are potential factors in the development of enfortumab vedotin resistance in urothelial carcinoma. Immunohistochemical evaluation of these proteins may aid in predicting treatment efficacy.

Details

Language :
English
ISSN :
2577171X
Volume :
7
Issue :
2
Database :
Directory of Open Access Journals
Journal :
IJU Case Reports
Publication Type :
Academic Journal
Accession number :
edsdoj.63bcc92766b349b79fab938d17d6b54a
Document Type :
article
Full Text :
https://doi.org/10.1002/iju5.12696