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Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM
- Source :
- Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
- Publication Year :
- 2016
- Publisher :
- Nature Portfolio, 2016.
-
Abstract
- ABHD5 is a co-activator of lipolysis. Here the authors show that in tumour-associated macrophages ABHD5 inhibits ROS-dependent induction of C/EBPÉ›, which transcriptionally activates spermidine synthase, and that blocking ABHD5 delays colorectal cancer growth in mice by inhibiting spermidine production.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 7
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.637eebb1c5495fbd40d2648ecc7300
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms11716