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MiR-124-3p negatively impacts embryo implantation via suppressing uterine receptivity formation and embryo development
- Source :
- Reproductive Biology and Endocrinology, Vol 22, Iss 1, Pp 1-14 (2024)
- Publication Year :
- 2024
- Publisher :
- BMC, 2024.
-
Abstract
- Abstract During embryo implantation, blastocyst interacts with the receptivity endometrium and the endometrial epithelium secretes nurturing fluid to support embryonic development. Interferon-λ (IFN-λ) is a novel, non-redundant regulator that participates in the fetal–maternal interaction; however, the precise molecular mechanism underlying its impact on uterine receptivity remains elusive. Here, microarray profiling revealed that 149 specific miRNAs were differentially expressed in the human endometrial cells following IFN-λ treatment. In particular, miR-124-3p expression was significantly reduced after IFN-λ treatment (p
Details
- Language :
- English
- ISSN :
- 14777827
- Volume :
- 22
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Reproductive Biology and Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.63613aeb974843458fbd49af5b477ab3
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s12958-024-01187-w