Plasmid-mediated metronidazole resistance in Clostridioides difficile

Authors :: Ilse M. Boekhoud
Bastian V. H. Hornung
Eloisa Sevilla
Céline Harmanus
Ingrid M. J. G. Bos-Sanders
Elisabeth M. Terveer
Rosa Bolea
Jeroen Corver
Ed J. Kuijper
Wiep Klaas Smits
Source :: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Publication Year :: 2020
Publisher :: Nature Portfolio, 2020.
Abstract: Cases of C. difficile (CD) resistant to metronidazole have been reported but the mechanism remains enigmatic. Here the authors identify a plasmid, which correlates with metronidazole resistance status in a large international collection of CD isolates, and demonstrate that the plasmid can confer metronidazole resistance.

Full Text Access

Tools