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CytofIn enables integrated analysis of public mass cytometry datasets using generalized anchors

Authors :
Yu-Chen Lo
Timothy J. Keyes
Astraea Jager
Jolanda Sarno
Pablo Domizi
Ravindra Majeti
Kathleen M. Sakamoto
Norman Lacayo
Charles G. Mullighan
Jeffrey Waters
Bita Sahaf
Sean C. Bendall
Kara L. Davis
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Challenges in batch normalization and data integration limit the comparison of existing mass cytometry datasets. Here, the authors report CytofIn that can integrate mass cytometry datasets from the public domain and reveal cellular features associated with immune oncology by analyzing five public cancer datasets.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.62feaf98a89e4b25a5f743a4912683d7
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-28484-5