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Antibodies to Combat Fungal Infections: Development Strategies and Progress

Authors :
Ali A. Rabaan
Amal H. Alfaraj
Amer Alshengeti
Abdulsalam Alawfi
Sara Alwarthan
Mashael Alhajri
Amal H. Al-Najjar
Mona A. Al Fares
Mustafa A. Najim
Souad A. Almuthree
Sultan T. AlShurbaji
Fadwa S. Alofi
Bashayer M. AlShehail
Buthina AlYuosof
Ahlam Alynbiawi
Suha A. Alzayer
Nawal Al Kaabi
Wesam A. Abduljabbar
Zakiyah A. Bukhary
Ahmed S. Bueid
Source :
Microorganisms, Vol 11, Iss 3, p 671 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

The finding that some mAbs are antifungal suggests that antibody immunity may play a key role in the defense of the host against mycotic infections. The discovery of antibodies that guard against fungi is a significant advancement because it gives rise to the possibility of developing vaccinations that trigger protective antibody immunity. These vaccines might work by inducing antibody opsonins that improve the function of non-specific (such as neutrophils, macrophages, and NK cells) and specific (such as lymphocyte) cell-mediated immunity and stop or aid in eradicating fungus infections. The ability of antibodies to defend against fungi has been demonstrated by using monoclonal antibody technology to reconsider the function of antibody immunity. The next step is to develop vaccines that induce protective antibody immunity and to comprehend the mechanisms through which antibodies mediate protective effects against fungus.

Details

Language :
English
ISSN :
20762607
Volume :
11
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Microorganisms
Publication Type :
Academic Journal
Accession number :
edsdoj.62f40b8d56274afba1dd71fb7b0a3901
Document Type :
article
Full Text :
https://doi.org/10.3390/microorganisms11030671