NiH-catalysed proximal-selective hydroalkylation of unactivated alkenes and the ligand effects on regioselectivity

Difunctionalization of olefins is an ongoing and important focus of synthetic organic chemistry. Here the authors report a nickel-catalysed hydroalkylation of unactivated alkenes to obtain branched alkyl carboxylic acids or alkyl amines, using aminoquinoline and picolinamide as directing groups.