Back to Search
Start Over
A clinically significant incidence of bleeding in critically ill children receiving therapeutic doses of unfractionated heparin: a prospective cohort study
- Source :
- Haematologica, Vol 92, Iss 2 (2007)
- Publication Year :
- 2007
- Publisher :
- Ferrata Storti Foundation, 2007.
-
Abstract
- Unfractionated heparin (UFH) is frequently prescribed for children for the prevention and treatment of thrombosis; however, its safety and efficacy have not been assessed. The aim of this single center, prospective cohort study was to determine the incidence of major bleeding and recurrent thrombosis in children receiving UFH. Major bleeding was defined a priori as: central nervous system or retroperitoneal bleeding, bleeding resulting in UFH being stopped or overt bleeding causing a drop in hemoglobin >20 g/dL in less than 24 h. Major bleeding events occurred in 9/38 children (24%, 95% CI 11–40%) and 2/38 (5%, 95% CI 0–18%) developed thrombosis. In conclusion, there is clinically significant bleeding in children receiving UFH.
- Subjects :
- Diseases of the blood and blood-forming organs
RC633-647.5
Subjects
Details
- Language :
- English
- ISSN :
- 03906078 and 15928721
- Volume :
- 92
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Haematologica
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.623192c5bad84c64be3afe30e78113de
- Document Type :
- article
- Full Text :
- https://doi.org/10.3324/haematol.10616