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Comparative study of β-cyclodextrin and carboxymethyl-β-cyclodextrin as effective drug delivery systems for oxymetholone: Design, preparation, characterization, phase solubility and in vitro drug release studies
- Source :
- Journal of Science: Advanced Materials and Devices, Vol 9, Iss 3, Pp 100751- (2024)
- Publication Year :
- 2024
- Publisher :
- Elsevier, 2024.
-
Abstract
- Cyclodextrins (CDs) are well-known agents in drug delivery systems as they can improve the physical properties of drugs with their distinctive features. Oxymetholone (OXYM) is a derivative of testosterone, a steroid drug that is widely used in the treatment of various diseases. In the current research, the inclusion complexes of OXYM with carboxymethyl-β-cyclodextrin (CM-β-CD/OXYM) and β-cyclodextrin (β-CD/OXYM) have been successfully prepared to improve stability, solubility, and biopharmaceutical profile of OXYM. The characterization of the prepared inclusion complexes was carried out using FT-IR, XRD, TGA, DLS, BET, and UV–Vis techniques. In addition, the morphology of the synthesized inclusion complexes was evaluated in terms of their FE-SEM images. The encapsulation efficiency (EE%), phase solubility, and in vitro drug release of the products were also evaluated using a simple spectrophotometric method. In addition, the kinetic study of in vitro drug release was conducted using the appropriate mathematical equations. In view of the findings of this study, a higher solubility was observed for CM-β-CD/OXYM compared to β-CD/OXYM, nearly three times higher. Furthermore, the in vitro drug release study indicated that β-CD/OXYM offers higher release rates, and the kinetic study demonstrated that both carriers follow a non-Fickian mechanism.
Details
- Language :
- English
- ISSN :
- 24682179
- Volume :
- 9
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Science: Advanced Materials and Devices
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.62190c3501f347389fbc9cd2b8f9eec5
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jsamd.2024.100751