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Toxins Targeting the KV1.3 Channel: Potential Immunomodulators for Autoimmune Diseases
- Source :
- Toxins, Vol 7, Iss 5, Pp 1749-1764 (2015)
- Publication Year :
- 2015
- Publisher :
- MDPI AG, 2015.
-
Abstract
- Autoimmune diseases are usually accompanied by tissue injury caused by autoantigen-specific T-cells. KV1.3 channels participate in modulating calcium signaling to induce T-cell proliferation, immune activation and cytokine production. Effector memory T (TEM)-cells, which play major roles in many autoimmune diseases, are controlled by blocking KV1.3 channels on the membrane. Toxins derived from animal venoms have been found to selectively target a variety of ion channels, including KV1.3. By blocking the KV1.3 channel, these toxins are able to suppress the activation and proliferation of TEM cells and may improve TEM cell-mediated autoimmune diseases, such as multiple sclerosis and type I diabetes mellitus.
- Subjects :
- toxins
KV1.3 channel
effector memory T-cell
autoimmune diseases
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 20726651
- Volume :
- 7
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- Toxins
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.620164cf07514f03b2296d459e451dcc
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/toxins7051749