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Anti-TBE Intrathecal Synthesis as a Prediction Marker in TBE Patients

Authors :
Agnieszka Siemieniako-Werszko
Piotr Czupryna
Anna Moniuszko-Malinowska
Justyna Dunaj-Małyszko
Sławomir Pancewicz
Sambor Grygorczuk
Joanna Zajkowska
Source :
Pathogens, Vol 11, Iss 4, p 416 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Tick-borne encephalitis (TBE) is an emerging vector-borne disease in Europe caused by tick-borne encephalitis virus (TBEV), which belongs to Flaviviridae. Although most of the patients quickly recover from TBE, some require further neurological and psychiatric treatment due to persistent symptoms. The aim of the study was to evaluate the usefulness of an antibodies index for predicting the course of the disease and potential persistent sequalae. Sixty-six patients (49 males and 17 females, mean age 45.97 ± 13.69 years) with TBE hospitalized in the Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Poland, in years 2016–2019 were included to the study. TBE antibodies titer in serum and CSF samples were measured with an Anti-TBEV ELISA (IgM, IgG) EUROIMMUN test. Patients who developed persistent sequelae after TBE had significantly lower IgG intrathecal index at admission. Additionally, IgG2/IgG1was significantly higher in patients who developed sequelae. IgG intrathecal index might be a useful tool for the prediction of TBE sequelae development.

Details

Language :
English
ISSN :
11040416 and 20760817
Volume :
11
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Pathogens
Publication Type :
Academic Journal
Accession number :
edsdoj.61ec2c6c432342fd9fb64cc55520a3c8
Document Type :
article
Full Text :
https://doi.org/10.3390/pathogens11040416