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Manipulation of sterol homeostasis for the production of 24-epi-ergosterol in industrial yeast

Authors :
Yiqi Jiang
Zhijiao Sun
Kexin Lu
Zeyu Wu
Hailong Xue
Li Zhu
Guosi Li
Yun Feng
Mianbin Wu
Jianping Lin
Jiazhang Lian
Lirong Yang
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Brassinolide (BL) is one of the most active compounds among phytohormone brassinosteroids (BRs) and can be used for plant growth and development regulation. Here, the authors report the construction of an artificial pathway in baker’s yeast for scalable production of 24-epi-ergosterol, a precursor for BL semi-synthesis.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.61dfd5b3fb024316a80764f64629d591
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-36007-z