Drug-induced liver injury in children: A nationwide cohort study from China

Authors :: Rongtao Lai
Xinjie Li
Jie Zhang
Jun Chen
Changqing Yang
Wen Xie
Yuecheng Yu
Xiaoyan Guo
Xinrong Zhang
Guoliang Lu
Xi’an Han
Qing Xie
Chengwei Chen
Tao Shen
Yimin Mao
Source :: JHEP Reports, Vol 6, Iss 8, Pp 101102- (2024)
Publication Year :: 2024
Publisher :: Elsevier, 2024.
Abstract: Background & Aims: Currently, there is limited knowledge on the clinical profile of drug-induced liver injury (DILI) in Chinese children. We aimed to assess the clinical characteristics, suspected drugs, and outcomes associated with pediatric DILI in China. Methods: This nationwide, multicenter, retrospective study, conducted between 2012 and 2014, analyzed 25,927 cases of suspected DILI at 308 medical centers using the inpatient medical register system. Utilizing the Roussel Uclaf causality assessment method score, only patients with scores ≥6 or diagnosed with DILI by three experts after scoring