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A Phase I/II randomized trial of H56:IC31 vaccination and adjunctive cyclooxygenase-2-inhibitor treatment in tuberculosis patients

Authors :
Synne Jenum
Kristian Tonby
Corina S. Rueegg
Morten Rühwald
Max P. Kristiansen
Peter Bang
Inge Christoffer Olsen
Kjersti Sellæg
Kjerstin Røstad
Tehmina Mustafa
Kjetil Taskén
Dag Kvale
Rasmus Mortensen
Anne Ma Dyrhol-Riise
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Modulating the host immune response during tuberculosis is an emerging and critical advance in the therapeutic approach. Here the authors present data from a first-in-human phase I/II randomised trial on the safety and immunogenicity of adjuvant therapy of the H56:IC31 vaccine and cyclooxygenase-2 inhibitors in patients with tuberculosis.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.6152a3f5e03b4794a0706ed5b7ac2925
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-27029-6