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A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry
- Source :
- Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- The SARS-CoV-2 spike protein contains a multi-basic cleavage site. Here, the authors show how this multi-basic cleavage site affects entry of SARS-CoV-2 into cells and transmission in the hamster model and identify host factors affecting entry of SARS-CoV-2 in a genome-wide CRISPR screen.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723 and 61419877
- Volume :
- 12
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.614198775ef44e57a0a5f7bb249a104c
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-021-21213-4