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Water‐Soluble Aggregation‐Induced Emission Luminogens with Near‐Infrared Emission for Advanced Phototheranostics

Authors :
Hanchen Shen
Changhuo Xu
Ruquan Ye
Tzu-Ming Liu
Jianyu Zhang
Ryan T. K. Kwok
Jacky W. Y. Lam
Zhihong Guo
Jianwei Sun
Ben Zhong Tang
Source :
Small Science, Vol 3, Iss 9, Pp n/a-n/a (2023)
Publication Year :
2023
Publisher :
Wiley-VCH, 2023.

Abstract

The development of water‐soluble aggregation‐induced emission luminogens (AIEgens) emitting in the near‐infrared (NIR) window holds promise for efficient biomedical applications. Nevertheless, synthesizing water‐soluble counterparts of NIR AIEgens presents difficulties due to their intrinsic hydrophobic properties. To address this issue, researchers have developed various molecular design strategies to improve the water solubility of NIR AIEgens. The integration of hydrophilic groups and targeting moieties is a crucial aspect of achieving precise phototheranostics. Here, diverse approaches to attain water‐soluble NIR AIEgens for biomedical applications are presented, and three commonly used strategies that involve decorating NIR AIEgens with positively or negatively charged groups, hydrophilic chains, and bioactive moieties are elaborated. These rational design strategies are believed to provide solutions for enhancing the water solubility and biological performance of NIR AIEgens in a single action. The remaining challenges and opportunities in this field are also discussed. The aim is to provide new insights into the design of water‐soluble NIR AIEgens and inspire more researchers to make significant contributions to this promising research area.

Details

Language :
English
ISSN :
26884046
Volume :
3
Issue :
9
Database :
Directory of Open Access Journals
Journal :
Small Science
Publication Type :
Academic Journal
Accession number :
edsdoj.60c6a798077f41ee905a99011eb7e810
Document Type :
article
Full Text :
https://doi.org/10.1002/smsc.202300052