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Haemodynamic implications of VA‐ECMO vs. VA‐ECMO plus Impella CP for cardiogenic shock in a large animal model
- Source :
- ESC Heart Failure, Vol 11, Iss 4, Pp 2305-2313 (2024)
- Publication Year :
- 2024
- Publisher :
- Wiley, 2024.
-
Abstract
- Abstract Aims Veno‐arterial extracorporeal membrane oxygenation (VA‐ECMO) with profound left ventricular (LV) failure is associated with inadequate LV emptying. To unload the LV, VA‐ECMO can be combined with Impella CP (ECMELLA). We hypothesized that ECMELLA improves cardiac energetics compared with VA‐ECMO in a porcine model of cardiogenic shock (CS). Methods and results Land‐race pigs (weight 70 kg) were instrumented, including a LV conductance catheter and a carotid artery Doppler flow probe. CS was induced with embolization in the left main coronary artery. CS was defined as reduction of ≥50% in cardiac output or mixed oxygen saturation (SvO2) or a SvO2
Details
- Language :
- English
- ISSN :
- 20555822
- Volume :
- 11
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- ESC Heart Failure
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6055bf778c624380a5ff4f5c672b96ee
- Document Type :
- article
- Full Text :
- https://doi.org/10.1002/ehf2.14780