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Haemodynamic implications of VA‐ECMO vs. VA‐ECMO plus Impella CP for cardiogenic shock in a large animal model

Authors :
Peter H. Frederiksen
Louise Linde
Emilie Gregers
Nanna L.J. Udesen
Ole K. Helgestad
Ann Banke
Jordi S. Dahl
Lisette O. Jensen
Jens F. Lassen
Amalie L. Povlsen
Jeppe P. Larsen
Henrik Schmidt
Hanne B. Ravn
Jacob E. Møller
Source :
ESC Heart Failure, Vol 11, Iss 4, Pp 2305-2313 (2024)
Publication Year :
2024
Publisher :
Wiley, 2024.

Abstract

Abstract Aims Veno‐arterial extracorporeal membrane oxygenation (VA‐ECMO) with profound left ventricular (LV) failure is associated with inadequate LV emptying. To unload the LV, VA‐ECMO can be combined with Impella CP (ECMELLA). We hypothesized that ECMELLA improves cardiac energetics compared with VA‐ECMO in a porcine model of cardiogenic shock (CS). Methods and results Land‐race pigs (weight 70 kg) were instrumented, including a LV conductance catheter and a carotid artery Doppler flow probe. CS was induced with embolization in the left main coronary artery. CS was defined as reduction of ≥50% in cardiac output or mixed oxygen saturation (SvO2) or a SvO2

Details

Language :
English
ISSN :
20555822
Volume :
11
Issue :
4
Database :
Directory of Open Access Journals
Journal :
ESC Heart Failure
Publication Type :
Academic Journal
Accession number :
edsdoj.6055bf778c624380a5ff4f5c672b96ee
Document Type :
article
Full Text :
https://doi.org/10.1002/ehf2.14780