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Oral fungal profiling and risk of nasopharyngeal carcinoma: a population-based case-control studyResearch in context

Authors :
Yufeng Chen
Wanxin Li
Ellen T. Chang
Justine W. Debelius
Lokeshwaran Manoharan
Yuming Zheng
Yancheng Li
Guangwu Huang
Hans-Olov Adami
Rob Knight
Yonglin Cai
Zhe Zhang
Weimin Ye
Source :
EBioMedicine, Vol 96, Iss , Pp 104813- (2023)
Publication Year :
2023
Publisher :
Elsevier, 2023.

Abstract

Summary: Background: Dysbiosis of the oral mycobiome has been linked to some diseases, including cancers. However, the role of oral fungal communities in nasopharyngeal carcinoma (NPC) carcinogenesis has not previously been investigated. Methods: We characterized the oral salivary fungal mycobiome in 476 untreated incident NPC patients and 537 population-based controls using fungal internal transcribed spacer (ITS)-2 sequencing. The relationship between oral fungal mycobiome and the risk of NPC was assessed through bioinformatic and biostatistical analyses. Findings: We found that lower fungal alpha diversity was associated with an increased odds of NPC [lower vs. higher: observed features (adjusted odds ratio [OR] = 5.81, 95% confidence interval [CI] = 3.60–9.38); Simpson diversity (1.53, 1.03–2.29); Shannon diversity (2.03, 1.35–3.04)]. We also observed a significant difference in global fungal community patterns between cases and controls based on Bray–Curtis dissimilarity (P

Details

Language :
English
ISSN :
23523964
Volume :
96
Issue :
104813-
Database :
Directory of Open Access Journals
Journal :
EBioMedicine
Publication Type :
Academic Journal
Accession number :
edsdoj.601bb010ccee48588ffeaae4c343b135
Document Type :
article
Full Text :
https://doi.org/10.1016/j.ebiom.2023.104813