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Identification of osteogenic progenitor cell-targeted peptides that augment bone formation

Authors :
Min Jiang
Ruiwu Liu
Lixian Liu
Alexander Kot
Xueping Liu
Wenwu Xiao
Junjing Jia
Yuanpei Li
Kit S. Lam
Wei Yao
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Activation of osteogenic cells is essential for bone regeneration. Here, the authors screen a peptide library and identify 2 compounds that promote osteogenic progenitor cell differentiation in vitro, and show that they increase bone formation and fracture repair in mice.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.5ff53e7e00854267b6246944d4363749
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-17417-9