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Incidence of Histoplasmosis in a Cohort of People with HIV: From Estimations to Reality

Authors :
Narda Medina
Juan Luis Rodriguez-Tudela
Luis Aguirre
Luis R. Salazar
Osmar Gamboa
Oscar Bonilla
Juan C. Pérez
Eduardo Arathoon
David W. Denning
Ana Alastruey-Izquierdo
Source :
Microorganisms, Vol 9, Iss 12, p 2596 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Among people with HIV, histoplasmosis represents an important cause of mortality. Previous studies provided estimates of the disease incidence. Here, we compared those estimates with the results obtained from a screening program implemented in Guatemala, which included histoplasmosis detection for people with HIV. To compare the results of this program with previous estimations, a literature search was performed and reports concerning histoplasmosis incidence were analyzed. The screening program enrolled 6366 patients. The overall histoplasmosis incidence in the screening program was 7.4%, which was almost double that estimated in previous studies. From 2017 to 2019, the screening program showed an upward trend in histoplasmosis cases from 6.5% to 8.8%. Histoplasmosis overall mortality among those who were newly HIV diagnosed showed a decrease at 180 days from 32.8% in 2017 to 21.2% in 2019. The screening approach using rapid diagnostic assays detects histoplasmosis cases more quickly, allowing a specific treatment to be administered, which decreases the mortality of the disease. Therefore, the use of these new techniques, especially in endemic areas of histoplasmosis, must be implemented.

Details

Language :
English
ISSN :
20762607
Volume :
9
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Microorganisms
Publication Type :
Academic Journal
Accession number :
edsdoj.5fd57b4cad0483f97f62a7986da964a
Document Type :
article
Full Text :
https://doi.org/10.3390/microorganisms9122596