The effect of lipopolysaccharide extracted from Pseudomonas aeruginosa on Total and Differential WBC and on Phagocytic activity

Lipopolysaccharide(LPS)was extracted from Pseudomonas aeruginosa by EDTA and the effect of the lipopolysaccharide of Pseudomonas aeruginosa was studied on the immune response of mice treated with LPS compared with untreated mice (control) . Total and defferential WBC count of peripheral blood and innate immune response represented by the phagocytic index were the criteria taken in to consideration . Result showed a significant increase in the total white blood cell count in the blood of mice treated with LPS with an increase in lymphocyte and Monocyte , and a decrease in neutophile and variation in Eosinophile was noticed in Blood films of Lps of treated mice, basophile was observed only in the Blood films of mice treated with concentration of 10 Mg/20g of body weight , An increase in the Non specific immune response was noticed through the increase of the phagocytic index .