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Antimicrobial Peptides and Their Applications in Biomedical Sector

Authors :
Afreen Sultana
Hongrong Luo
Seeram Ramakrishna
Source :
Antibiotics, Vol 10, Iss 9, p 1094 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

In a report by WHO (2014), it was stated that antimicrobial resistance is an arising challenge that needs to be resolved. This resistance is a critical issue in terms of disease or infection treatment and is usually caused due to mutation, gene transfer, long-term usage or inadequate use of antimicrobials, survival of microbes after consumption of antimicrobials, and the presence of antimicrobials in agricultural feeds. One of the solutions to this problem is antimicrobial peptides (AMPs), which are ubiquitously present in the environment. These peptides are of concern due to their special mode of action against a wide spectrum of infections and health-related problems. The biomedical field has the highest need of AMPs as it possesses prominent desirable activity against HIV-1, skin cancer, breast cancer, in Behcet’s disease treatment, as well as in reducing the release of inflammatory cells such as TNFα, IL-8, and IL-1β, enhancing the production of anti-inflammatory cytokines such as IL-10 and GM-CSF, and in wound healing properties. This review has highlighted all the major functions and applications of AMPs in the biomedical field and concludes the future potential of AMPs.

Details

Language :
English
ISSN :
20796382
Volume :
10
Issue :
9
Database :
Directory of Open Access Journals
Journal :
Antibiotics
Publication Type :
Academic Journal
Accession number :
edsdoj.5f871eeb00604ae4a045b44327b4cc11
Document Type :
article
Full Text :
https://doi.org/10.3390/antibiotics10091094