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CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer
- Source :
- Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
- Publication Year :
- 2023
- Publisher :
- Nature Portfolio, 2023.
-
Abstract
- Identifying prostate cancer patients who may respond well to PARP inhibitors is important for their success in the clinic. Here, using a genome-wide CRISPR-Cas9 knockout screen, the authors identify MMS22L as a biomarker for sensitivity to PARP inhibition in BRCA1/2-proficient prostate cancer.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 14
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5f553e58e5416b821643fde0923364
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-023-35880-y