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Antibody-mediated Rejection in Kidney Transplant: An Unmastered Area

Authors :
Shahul Valavoor
Manish Anand
Amit Govil
Source :
Indian Journal of Transplantation, Vol 18, Iss 2, Pp 101-108 (2024)
Publication Year :
2024
Publisher :
Wolters Kluwer Medknow Publications, 2024.

Abstract

Antibody-mediated rejection (ABMR) remains a significant cause of allograft failure in patients with kidney transplantation. Despite successful strategies to treat ABMR, irreversible injury in the form of transplant glomerulopathy commonly manifests months to years later. Treatment for ABMR is not standardized, and treatment guidelines vary among different transplant centers. The outcomes for patients at risk for ABMR have not significantly changed over the years. This is largely because of an incomplete understanding of the mechanisms of injury responsible for different phenotypes of ABMR. Establishing relevant surrogate endpoints to facilitate more informative studies will likely allow for a more accurate determination of prognosis and pave the way for new and effective therapeutic approaches. This article aims to summarize the current understanding of the mechanism of injury in ABMR and highlight current diagnostic approaches and treatment strategies.

Details

Language :
English
ISSN :
22120017 and 22120025
Volume :
18
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Indian Journal of Transplantation
Publication Type :
Academic Journal
Accession number :
edsdoj.5f31418a5da4b6d8a066bbe94c023e1
Document Type :
article
Full Text :
https://doi.org/10.4103/ijot.ijot_129_23