Back to Search
Start Over
Treatment of patients with ethylene glycol or methanol poisoning: focus on fomepizole
- Source :
- Open Access Emergency Medicine, Vol 2010, Iss default, Pp 67-75 (2010)
- Publication Year :
- 2010
- Publisher :
- Dove Medical Press, 2010.
-
Abstract
- Bruno MégarbaneRéanimation Médicale et Toxicologique, Hôpital Lariboisière and Université Paris-Diderot, Paris, FranceAbstract: Ethylene glycol (EG) and methanol are responsible for life-threatening poisonings. Fomepizole, a potent alcohol dehydrogenase (ADH) inhibitor, is an efficient and safe antidote that prevents or reduces toxic EG and methanol metabolism. Although no study has compared its efficacy with ethanol, fomepizole is recommended as a first-line antidote. Treatment should be started as soon as possible, based on history and initial findings including anion gap metabolic acidosis, while awaiting measurement of alcohol concentration. Administration is easy (15 mg/kg-loading dose, either intravenously or orally, independent of alcohol concentration, followed by intermittent 10 mg/kg-doses every 12 hours until alcohol concentrations are
- Subjects :
- Medical emergencies. Critical care. Intensive care. First aid
RC86-88.9
Subjects
Details
- Language :
- English
- ISSN :
- 11791500
- Volume :
- 2010
- Issue :
- default
- Database :
- Directory of Open Access Journals
- Journal :
- Open Access Emergency Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5ef83ff11bc348aeba1310d75f462fa3
- Document Type :
- article