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Structural basis for lipid and copper regulation of the ABC transporter MsbA

Authors :
Jixing Lyu
Chang Liu
Tianqi Zhang
Samantha Schrecke
Nicklaus P. Elam
Charles Packianathan
Georg K. A. Hochberg
David Russell
Minglei Zhao
Arthur Laganowsky
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

The bacterial ABC transporter MsbA is essential for lipopolysaccharide biogenesis. Here, the authors apply native mass spectrometry, X-ray crystallography, cryo-EM and biochemical approaches to characterize the structural basis and functional roles of MsbA binding to copper and specific lipids.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.5e9d0f15449143aebe7c810597dff7e1
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-34905-2