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Examination of the expression levels of MACC1, Filamin A and FBXW7 genes in colorectal cancer patients

Authors :
Funda Yeşilkaya
Didem Tastekin
Hani Al Saadoni
Arzu Ergen
Sadrettin Pence
Source :
İstanbul Kuzey Klinikleri, Vol 7, Iss 1, Pp 1-5 (2020)
Publication Year :
2020
Publisher :
KARE Publishing, 2020.

Abstract

OBJECTIVE: Colorectal cancer (CRC) is the third most common type of cancer observed in cancer-related mortality because it has a high metastasis ratio. This study aims to investigate the expression levels of several genes, including metastasis-related colon cancer 1 (MACC1), Filamin A (FLNA), F-box/WD repeat-containing protein 7 (FBXW7), which has an important role in cell signaling, migration and adhesion through the remodeling of the cell skeleton. METHODS: In this study, 21 patients with a precise diagnosis of CRC and 21 controls were included. Gene expressions were examined using the RT-PCR technique. To define the relationship of the genes with metastasis, blood samples were collected from all patients with colon/rectal cancer diagnosis without metastasis at six months before and after the medication with Xelox. RESULTS: Our findings showed that no significant difference was observed in the pre-treatment values compared to the control group, whereas FLNA (p=0.001) expression was observed to be significantly increased following treatment with Xelox. CONCLUSION: To our knowledge, our study is the first study to investigate the effects of Xelox treatment on the expression levels of MACC1, FBXW7 and FLNA genes in non-metastatic colorectal cancer patients in Turkey.

Details

Language :
English
ISSN :
21484902
Volume :
7
Issue :
1
Database :
Directory of Open Access Journals
Journal :
İstanbul Kuzey Klinikleri
Publication Type :
Academic Journal
Accession number :
edsdoj.5e6b72d5b652424e8b892227d2bcf699
Document Type :
article
Full Text :
https://doi.org/10.14744/nci.2019.26780