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Examination of the expression levels of MACC1, Filamin A and FBXW7 genes in colorectal cancer patients
- Source :
- İstanbul Kuzey Klinikleri, Vol 7, Iss 1, Pp 1-5 (2020)
- Publication Year :
- 2020
- Publisher :
- KARE Publishing, 2020.
-
Abstract
- OBJECTIVE: Colorectal cancer (CRC) is the third most common type of cancer observed in cancer-related mortality because it has a high metastasis ratio. This study aims to investigate the expression levels of several genes, including metastasis-related colon cancer 1 (MACC1), Filamin A (FLNA), F-box/WD repeat-containing protein 7 (FBXW7), which has an important role in cell signaling, migration and adhesion through the remodeling of the cell skeleton. METHODS: In this study, 21 patients with a precise diagnosis of CRC and 21 controls were included. Gene expressions were examined using the RT-PCR technique. To define the relationship of the genes with metastasis, blood samples were collected from all patients with colon/rectal cancer diagnosis without metastasis at six months before and after the medication with Xelox. RESULTS: Our findings showed that no significant difference was observed in the pre-treatment values compared to the control group, whereas FLNA (p=0.001) expression was observed to be significantly increased following treatment with Xelox. CONCLUSION: To our knowledge, our study is the first study to investigate the effects of Xelox treatment on the expression levels of MACC1, FBXW7 and FLNA genes in non-metastatic colorectal cancer patients in Turkey.
Details
- Language :
- English
- ISSN :
- 21484902
- Volume :
- 7
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- İstanbul Kuzey Klinikleri
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5e6b72d5b652424e8b892227d2bcf699
- Document Type :
- article
- Full Text :
- https://doi.org/10.14744/nci.2019.26780