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How Stem and Progenitor Cells Can Affect Renal Diseases

Authors :
Francesca Montenegro
Francesca Giannuzzi
Angela Picerno
Antonella Cicirelli
Emma Diletta Stea
Vincenzo Di Leo
Fabio Sallustio
Source :
Cells, Vol 13, Iss 17, p 1460 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Stem and progenitor cells have been observed to contribute to regenerative processes in acute renal failure and chronic kidney disease. Recent research has delved into the intricate mechanisms by which stem and progenitor cells exert their influence on kidney diseases. Understanding how these cells integrate with the existing renal architecture and their response to injury could pave the way for innovative treatment strategies aimed at promoting kidney repair and regeneration. Overall, the role of stem and progenitor cells in kidney diseases is multifaceted, with their ability to contribute to tissue regeneration, immune modulation, and the maintenance of renal homeostasis. Here, we review the studies that we have available today about the involvement of stem and progenitor cells both in regenerative therapies and in the causes of renal diseases, as well as in natural healing mechanisms, taking into account the main kidney disorders, such as IgA nephropathy, lupus nephritis, diabetic nephropathy, C3 glomerulopathy, focal segmental glomerulosclerosis, idiopathic membranous nephropathy, anti-glomerular basement membrane glomerulonephritis, and ANCA-associated crescentic glomerulonephritis. Moreover, based on the comprehensive data available in the framework of the specific kidney diseases on stem cells and renal progenitors, we hypothesize a possible role of adult renal progenitors in exacerbating or recovering the illness.

Details

Language :
English
ISSN :
20734409
Volume :
13
Issue :
17
Database :
Directory of Open Access Journals
Journal :
Cells
Publication Type :
Academic Journal
Accession number :
edsdoj.5d94a4cc3d144d7929a16878d595c96
Document Type :
article
Full Text :
https://doi.org/10.3390/cells13171460