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Glycosylating Effectors of Legionella pneumophila: Finding the Sweet Spots for Host Cell Subversion

Authors :
Yury Belyi
Nadya Levanova
Gunnar N. Schroeder
Source :
Biomolecules, Vol 12, Iss 2, p 255 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Work over the past two decades clearly defined a significant role of glycosyltransferase effectors in the infection strategy of the Gram-negative, respiratory pathogen Legionella pneumophila. Identification of the glucosyltransferase effectors Lgt1-3, specifically modifying elongation factor eEF1A, disclosed a novel mechanism of host protein synthesis manipulation by pathogens and illuminated its impact on the physiological state of the target cell, in particular cell cycle progression and immune and stress responses. Recent characterization of SetA as a general O-glucosyltransferase with a wide range of targets including the proteins Rab1 and Snx1, mediators of membrane transport processes, and the discovery of new types of glycosyltransferases such as LtpM and SidI indicate that the vast effector arsenal might still hold more so-far unrecognized family members with new catalytic features and substrates. In this article, we review our current knowledge regarding these fascinating biomolecules and discuss their role in introducing new or overriding endogenous post-translational regulatory mechanisms enabling the subversion of eukaryotic cells by L. pneumophila.

Details

Language :
English
ISSN :
2218273X
Volume :
12
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Biomolecules
Publication Type :
Academic Journal
Accession number :
edsdoj.5d21bbff384d439f86a445b956d94569
Document Type :
article
Full Text :
https://doi.org/10.3390/biom12020255