Back to Search Start Over

Suppression of preadipocyte determination by SOX4 limits white adipocyte hyperplasia in obesity

Authors :
Ting He
Shuai Wang
Shengnan Li
Huanming Shen
Lingfeng Hou
Yunjia Liu
Yixin Wei
Fuan Xie
Zhiming Zhang
Zehang Zhao
Chunli Mo
Huiling Guo
Qingsong Huang
Rui Zhang
Dongyan Shen
Boan Li
Source :
iScience, Vol 26, Iss 4, Pp 106289- (2023)
Publication Year :
2023
Publisher :
Elsevier, 2023.

Abstract

Summary: Preadipocyte determination expanding the pool of preadipocytes is a vital process in adipocyte hyperplasia, but the molecular mechanisms underlying this process are yet to be elucidated. Herein, SRY-related HMG box transcription factor 4 (SOX4) was identified as a critical target in response to BMP4- and TGFβ-regulated preadipocyte determination. SOX4 deficiency is sufficient to promote preadipocyte determination in mesenchymal stem cells (MSCs) and acquisition of preadipocyte properties in nonadipogenic lineages, while its overexpression impairs the adipogenic capacity of preadipocytes and converts them into nonadipogenic lineages. Mechanism studies indicated that SOX4 activates and cooperates with LEF1 to retain the nuclear localization of β-catenin, thus mediating the crosstalk between TGFβ/BMP4 signaling pathway and Wnt signaling pathway to regulate the preadipocyte determination. In vivo studies demonstrated that SOX4 promotes the adipogenic-nonadipogenic conversion and suppresses the adipocyte hyperplasia. Together, our findings highlight the importance of SOX4 in regulating the adipocyte hyperplasia in obesity.

Details

Language :
English
ISSN :
25890042
Volume :
26
Issue :
4
Database :
Directory of Open Access Journals
Journal :
iScience
Publication Type :
Academic Journal
Accession number :
edsdoj.5d20035dce284c31b6a47a8309589523
Document Type :
article
Full Text :
https://doi.org/10.1016/j.isci.2023.106289