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Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Authors :
Edith Hofer
Gennady V. Roshchupkin
Hieab H. H. Adams
Maria J. Knol
Honghuang Lin
Shuo Li
Habil Zare
Shahzad Ahmad
Nicola J. Armstrong
Claudia L. Satizabal
Manon Bernard
Joshua C. Bis
Nathan A. Gillespie
Michelle Luciano
Aniket Mishra
Markus Scholz
Alexander Teumer
Rui Xia
Xueqiu Jian
Thomas H. Mosley
Yasaman Saba
Lukas Pirpamer
Stephan Seiler
James T. Becker
Owen Carmichael
Jerome I. Rotter
Bruce M. Psaty
Oscar L. Lopez
Najaf Amin
Sven J. van der Lee
Qiong Yang
Jayandra J. Himali
Pauline Maillard
Alexa S. Beiser
Charles DeCarli
Sherif Karama
Lindsay Lewis
Mat Harris
Mark E. Bastin
Ian J. Deary
A. Veronica Witte
Frauke Beyer
Markus Loeffler
Karen A. Mather
Peter R. Schofield
Anbupalam Thalamuthu
John B. Kwok
Margaret J. Wright
David Ames
Julian Trollor
Jiyang Jiang
Henry Brodaty
Wei Wen
Meike W. Vernooij
Albert Hofman
André G. Uitterlinden
Wiro J. Niessen
Katharina Wittfeld
Robin Bülow
Uwe Völker
Zdenka Pausova
G. Bruce Pike
Sophie Maingault
Fabrice Crivello
Christophe Tzourio
Philippe Amouyel
Bernard Mazoyer
Michael C. Neale
Carol E. Franz
Michael J. Lyons
Matthew S. Panizzon
Ole A. Andreassen
Anders M. Dale
Mark Logue
Katrina L. Grasby
Neda Jahanshad
Jodie N. Painter
Lucía Colodro-Conde
Janita Bralten
Derrek P. Hibar
Penelope A. Lind
Fabrizio Pizzagalli
Jason L. Stein
Paul M. Thompson
Sarah E. Medland
ENIGMA consortium
Perminder S. Sachdev
William S. Kremen
Joanna M. Wardlaw
Arno Villringer
Cornelia M. van Duijn
Hans J. Grabe
William T. Longstreth
Myriam Fornage
Tomas Paus
Stephanie Debette
M. Arfan Ikram
Helena Schmidt
Reinhold Schmidt
Sudha Seshadri
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.5d16e85f224b486f9cfab04f0d940bed
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-18367-y