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Hirschsprung-associated enterocolitis: a comprehensive review
- Source :
- World Journal of Pediatric Surgery, Vol 7, Iss 3 (2024)
- Publication Year :
- 2024
- Publisher :
- BMJ Publishing Group, 2024.
-
Abstract
- Hirschsprung-associated enterocolitis (HAEC) is an important cause of morbidity and the leading cause of mortality in patients with Hirschsprung disease. The pathophysiology of disease includes dysmotility of the enteric nervous system, dysbiosis of the microbiota, failure of the intestinal barrier, and impaired immunity. Common manifestations include fever, abdominal distension, lethargy, vomiting, and diarrhea. Given the non-specific signs and symptoms of HAEC, high clinical suspicion is warranted, especially in patients with risk factors. Diagnosis and management of HAEC depend on the severity of disease presentation. Several preoperative and postoperative modalities have been explored to prevent HAEC. The current review elaborates on the risk factors, pathogenesis, diagnosis, treatment, and prevention of HAEC.
- Subjects :
- Pediatrics
RJ1-570
Surgery
RD1-811
Subjects
Details
- Language :
- English
- ISSN :
- 25165410
- Volume :
- 7
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- World Journal of Pediatric Surgery
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5ce2431de50f44d896adac07dfd9d8ee
- Document Type :
- article
- Full Text :
- https://doi.org/10.1136/wjps-2024-000878