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Stable contacts of naïve CD4 T cells with migratory dendritic cells are ICAM-1-dependent but dispensable for proliferation in vivo
- Source :
- Cell Adhesion & Migration, Vol 13, Iss 1, Pp 314-320 (2019)
- Publication Year :
- 2019
- Publisher :
- Taylor & Francis Group, 2019.
-
Abstract
- It is unclear if naïve T cells require dendritic cell ICAMs to proliferate inside lymph nodes. To check if and when CD4 lymphocytes use ICAMs on migratory DCs, wild-type and ICAM-1 and 2 double knock out bone marrow-derived DCs pulsed with saturating levels of an OT-II transgene-specific ovalbumin-derived peptide were co-transferred into skin-draining lymph nodes. Intravital imaging of OT-II lymphocytes entering these lymph nodes revealed that ICAM-1 and −2 deficient migratory DCs formed fewer stable conjugates with OT-II lymphocytes but promoted normal T cell proliferation. DC ICAMs were also not required for unstable TCR-dependent lymphocyte arrests on antigen presenting migratory DCs. Thus, rare antigen-stimulated ICAM-stabilized T-DC conjugates are dispensable for CD4 lymphocyte proliferation inside lymph nodes.
- Subjects :
- lymph nodes
dendritic cells
integrins
t cell activation
vaccination
Cytology
QH573-671
Subjects
Details
- Language :
- English
- ISSN :
- 19336918 and 19336926
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Cell Adhesion & Migration
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5cc387acedf745ec8c71bb10581837c8
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/19336918.2019.1644857