Back to Search
Start Over
Concise Synthesis of Broussonone A
- Source :
- Molecules, Vol 20, Iss 9, Pp 15966-15975 (2015)
- Publication Year :
- 2015
- Publisher :
- MDPI AG, 2015.
-
Abstract
- A concise and expeditious approach to the total synthesis of broussonone A, a p-quinol natural compound, has been developed. The key features of the synthesis include the Grubbs II catalyst mediated cross metathesis of two aromatic subunits, and a chemoselective oxidative dearomatizationin the presence of two phenol moieties. Especially, optimization associated with the CM reaction of ortho-alkoxystyrenes was also studied, which are known to be ineffective for Ru-catalyzed metathesis reactions under conventional reaction conditions because ortho-alkoxy group could coordinate to the ruthenium center, resulting in the potential complication of catalyst inhibition.
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 20
- Issue :
- 9
- Database :
- Directory of Open Access Journals
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5c9ac6f62f3421cab71a99625cb423d
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/molecules200915966