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Early Antibody-Mediated Kidney Transplant Rejection: A Successful Case Without Donor-Specific Anti-HLA Antibodies
- Source :
- Revista Portuguesa de Nefrologia e Hipertensão, Vol 37, Iss 2, Pp 89-92 (2023)
- Publication Year :
- 2023
- Publisher :
- Publicações Ciência e Vida, 2023.
-
Abstract
- The diagnosis of antibody-mediated rejection has become more common and represents a major cause of kidney graft loss. The ideal treatment remains unknown, with little evidence supporting the use of a specific therapy. The definition of antibody-mediated rejection is based on serologic (presence and/or development of donor-specific antibodies) and histologic (evidence of acute tissue injury with C4d deposition or other signs of antibody interaction with the vascular endothelium) criteria. Antibody-mediated rejection without donor-specific antibodies is a subcategory with a defying diagnosis. This particularly entity is increasingly being reported as an important cause of allograft dysfunction in kidney transplantation. We describe the case of a kidney transplant recipient with a low immunological risk and delayed graft function due to an antibody-mediated rejection with negative donor-specific antibodies.
Details
- Language :
- English
- ISSN :
- 08720169 and 21831289
- Volume :
- 37
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Revista Portuguesa de Nefrologia e Hipertensão
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5c92b032b4a74586b3d779e94aa658ca
- Document Type :
- article
- Full Text :
- https://doi.org/10.32932/pjnh.2023.05.239