Back to Search
Start Over
Diagnostic Performance and Comparative Analysis of Conventional Drug Susceptibility Testing, Line Probe Assay, and GeneXpert in Extrapulmonary Tuberculosis Cases: A Cross-sectional Observational Study
- Source :
- Journal of Clinical and Diagnostic Research, Vol 18, Iss 02, Pp 11-14 (2024)
- Publication Year :
- 2024
- Publisher :
- JCDR Research and Publications Private Limited, 2024.
-
Abstract
- Introduction: Tuberculosis (TB), a known threat to mankind for ages, causes a significant burden on healthcare worldwide. The alarming rise of Extrapulmonary Tuberculosis (EPTB) has led healthcare professionals to opt for molecular diagnostics. Despite the availability of rapid diagnostics, conventional culture Drug Susceptibility Testing (DST) is still considered the gold standard in diagnosing TB. Aim: To assess the diagnostic accuracy of culture DST which is considered the gold standard. Materials and Methods: This cross-sectional observational study included 150 suspected EPTB patients and was conducted over a period of one year (September 2018 to August 2019) at Lokmanya Tilak Municipal Medical College and Sion Hospital (LTMMC), a tertiary care hospital in central Mumbai, Maharashtra, India. The hospital is located adjacent to Dharavi, the largest slum area with a high population density, which contributes to the majority of patients attending clinics. Patients attending the pulmonary medicine Outpatient Department (OPD) with extrapulmonary manifestations and suspected cases of EPTB were enrolled in the study. Samples, excluding sputum, were sent to the Department of Microbiology, LTMMC, Sion Hospital for GeneXpert analysis. The samples were further evaluated by microscopy, GeneXpert, and culture DST to detect the presence of Mycobacterium tuberculosis (M. tuberculosis) and drug susceptibility, respectively. Patients positive for Pulmonary Tuberculosis (PTB) were excluded from the study. Categorical variables were described using percentages. A Chi-square test was applied, and a p-value of
- Subjects :
- antitubercular drugs
diagnosis
drug resistance
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 2249782X and 0973709X
- Volume :
- 18
- Issue :
- 02
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Clinical and Diagnostic Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5c748db51ad142738b3275b855d8b595
- Document Type :
- article
- Full Text :
- https://doi.org/10.7860/JCDR/2024/64599.19095