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Reactivation of SARS-CoV-2 infection following recovery from COVID-19

Reactivation of SARS-CoV-2 infection following recovery from COVID-19

Authors :
Zhihai Chen
Wen Xie
Ziruo Ge
Yajie Wang
Hong Zhao
Jingjing Wang
Yanli Xu
Wei Zhang
Meihua Song
Shuping Cui
Xiankun Wang
Calvin Q. Pan
Source :
Journal of Infection and Public Health, Vol 14, Iss 5, Pp 620-627 (2021)
Publication Year :
2021
Publisher :
Elsevier, 2021.

Abstract

Introduction: Many individuals test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA after recovering from the coronavirus disease (COVID-19), but the incidence of reactivation is unknown. We, therefore, estimated the incidence of reactivation among individuals who had recovered from COVID-19 and determined its predictors. Methods: In this retrospective cohort study, patients with COVID-19 were followed up for at least 14 days after two consecutive negative SARS-CoV-2 polymerase chain reaction test results obtained ≥24 h apart, and the frequency of SARS-CoV-2 reactivation was assessed. Results: Of the 109 patients, 29 (27%) experienced reactivation, and seven (24%) of these were symptomatic. The mean period for the real-time PCR tests for SARS-CoV-2 from negative to positive results was 17 days. Compared with patients without reactivation, those with reactivation were significantly younger and more likely to have a lymphocyte count of

Details

Language :
English
ISSN :
18760341
Volume :
14
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Journal of Infection and Public Health
Publication Type :
Academic Journal
Accession number :
edsdoj.5c40a74aee477e9318eb5999a033ba
Document Type :
article
Full Text :
https://doi.org/10.1016/j.jiph.2021.02.002