FABP4 gene expression in subcutaneous and visceral adipose tissue in patients with obesity and type 2 diabetes mellitus

Authors :: K. V. Dracheva
I. A. Pobozheva
K. A. Anisimova
Z. M. Hamid
A. P. Sapojnikova
S. G. Balandov
D. I. Vasilevsky
S. N. Pchelina
V. V. Miroshnikova
Source :: Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, Vol 29, Iss 1, Pp 46-53 (2022)
Publication Year :: 2022
Publisher :: Academician I.P. Pavlov First St. Petersburg State Medical University, 2022.
Abstract: Introduction. Obesity is associated with a high risk of developing concomitant diseases such as: metabolic syndrome, type 2 diabetes mellitus (DM2), cardiovascular pathology. FABP4 (fatty acid binding protein) is the specific lipid chaperone and an important protein for the function of adipose tissue and is one of the adipocytokines secreted by adipose tissue.The objective of the study was to investigate the FABP4 gene expression in subcutaneous and visceral adipose tissue (SAT and VAT) in patients with obesity and DM2.Methods and materials. SAT and VAT samples were obtained during bariatric surgery (N=43, BMI>35): obese with DM2 (N=21), obese without DM2 (N=22). Samples for the control group without obesity (N=15, BMI

Subjects :: fabp4
obesity
type 2 diabetes mellitus
adipose tissue
Medicine (General)
R5-920

Language :: Russian
ISSN :: 16074181 and 25418807
Volume :: 29
Issue :: 1
Database :: Directory of Open Access Journals
Journal :: Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова
Publication Type :: Academic Journal
Accession number :: edsdoj.5c31b8a473ea42fb858e77b781274000
Document Type :: article
Full Text :: https://doi.org/10.24884/1607-4181-2022-29-1-46-53

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