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The Impact of RNA Interference in Tick Research

Authors :
José de la Fuente
Katherine M. Kocan
Source :
Pathogens, Vol 11, Iss 8, p 827 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Over the past two decades, RNA interference (RNAi) in ticks, in combination with omics technologies, have greatly advanced the discovery of tick gene and molecular function. While mechanisms of RNAi were initially elucidated in plants, fungi, and nematodes, the classic 2002 study by Aljamali et al. was the first to demonstrate RNAi gene silencing in ticks. Subsequently, applications of RNAi have led to the discovery of genes that impact tick function and tick-host-pathogen interactions. RNAi will continue to lead to the discovery of an array of tick genes and molecules suitable for the development of vaccines and/or pharmacologic approaches for tick control and the prevention of pathogen transmission.

Details

Language :
English
ISSN :
20760817
Volume :
11
Issue :
8
Database :
Directory of Open Access Journals
Journal :
Pathogens
Publication Type :
Academic Journal
Accession number :
edsdoj.5c1d39f5bd1546499214c316aa0e093e
Document Type :
article
Full Text :
https://doi.org/10.3390/pathogens11080827