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Timing the initiation of multiple myeloma

Authors :
Even H. Rustad
Venkata Yellapantula
Daniel Leongamornlert
Niccolò Bolli
Guy Ledergor
Ferran Nadeu
Nicos Angelopoulos
Kevin J. Dawson
Thomas J. Mitchell
Robert J. Osborne
Bachisio Ziccheddu
Cristiana Carniti
Vittorio Montefusco
Paolo Corradini
Kenneth C. Anderson
Philippe Moreau
Elli Papaemmanuil
Ludmil B. Alexandrov
Xose S. Puente
Elias Campo
Reiner Siebert
Herve Avet-Loiseau
Ola Landgren
Nikhil Munshi
Peter J. Campbell
Francesco Maura
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

The initial mutational processes and how these lead to progression in multiple myeloma (MM) are unclear. Here, the authors identify mutational signatures that occur over time in a large cohort of MM patients and suggest features that may help in early diagnosis.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.5bcecbd98cdc4f9fbf76239987880049
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-15740-9