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Preclinical evaluation of Hibiscus cannabinus Linn. in the treatment of urolithiasis and cholelithiasis
- Source :
- Digital Chinese Medicine, Vol 6, Iss 2, Pp 189-197 (2023)
- Publication Year :
- 2023
- Publisher :
- KeAi Communications Co., Ltd., 2023.
-
Abstract
- Objective: To investigate the therapeutic effect of Hibiscus cannabinus Linn. (H. cannabinus) leaves on cholelithiasis and urolithiasis. Methods: The study evaluated the effect of aqueous leaf extract of H. cannabinus on thiouracil and cholesterol cholic acid diet induced cholelithiasis in BALB/c mice and ethylene glycol induced urolithiasis in Wistar rats. Three doses of aqueous extract (40, 80, and 160 mg/kg) were selected to evaluate the effectiveness in cholelithiasis in mice; another three doses of aqueous extract (400, 800, and 1600 mg/kg) were administered for evaluating the effect on urolithiasis in rats. Biochemical parameters such as biliary cholesterol, biliary phospholipid, and bile acid were determined in cholelithiasis model. Similarly, 24-hour urine output, urinary parameters such as creatinine, uric acid, protein, urea, presence of calcium oxalate crystals, red blood cells (RBCs), and pyuria were determined in urolithiasis model. Results: Statistically significant differences were noted in the biliary and urinary parameters after administrating three test doses of H. cannabinus aqueous extract (P < 0.05). Conclusion: H. cannabinus was found to be effective against high fat lithogenic diet urolithiasis and cholelithiasis.
Details
- Language :
- English
- ISSN :
- 25893777
- Volume :
- 6
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Digital Chinese Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5ba9665001ca46ca9bcd2abc44829274
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.dcmed.2023.07.008