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New mechanisms of the TCM spleen-based treatment of immune thrombocytopenia purpura from the perspective of blood neurotransmitters
- Source :
- Journal of Traditional Chinese Medical Sciences, Vol 4, Iss 2, Pp 106-112 (2017)
- Publication Year :
- 2017
- Publisher :
- Elsevier, 2017.
-
Abstract
- Objective: To explore new mechanisms of the traditional Chinese medicine (TCM) spleen-based treatment of immune thrombocytopenic purpura (ITP) from the perspective of blood neurotransmitters. Methods: In this randomized controlled multi-center clinical study, 271 ITP patients who met the diagnostic criteria of “syndrome of spleen failing to manage blood” were randomized into three groups: group A administered Jianpi Yiqi Shexue (JYS) granules, 1 bag per treatment, bid; group C administered prednisone as a draught at an initial dose of 1.0–1.5 mg/kg/day at 8:00 AM; and group B administered a combination of the interventions in groups A and C. Each treatment cycle lasted 21 days. Results: After treatment, scores of platelet distribution width (PDW) were significantly decreased in groups B and C, and there were significant differences among the three groups (P = .0131). Pairwise comparisons showed that PDW was significantly different between group A and group B (P = .005) and between group A and group C (P = .041) but not between group B and group C. Hemorrhage grading scores were significantly different between day 1 and day 7 in group A and group B (P .05). Serum β-endorphin and vasoactive intestinal peptide levels were significantly different between group A and group B (both P
Details
- Language :
- English
- ISSN :
- 20957548
- Volume :
- 4
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Traditional Chinese Medical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5b8c9d2882e54e1e8ef8919414999bb1
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jtcms.2017.08.002