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Unaltered low nerve growth factor and high brain-derived neurotrophic factor levels in plasma from patients with fibromyalgia after a 15-week progressive resistance exercise
- Source :
- Journal of Rehabilitation Medicine, Vol 51, Iss 10, Pp 779-787 (2019)
- Publication Year :
- 2019
- Publisher :
- Medical Journals Sweden, 2019.
-
Abstract
- Background: The pathophysiology of fibromyalgia includes central and peripheral factors. Neurotrophins, such as nerve growth factor and brain-derived neurotrophic factor, are involved in peripheral and central nervous system development of pain and hyperalgesia. Few studies have examined circulating nerve growth factor and brain-derived neurotrophic factor in fibromyalgia or have investigated whether exercise interventions affect the levels of these peptides. Objectives: To compare plasma levels of nerve growth factor and brain-derived neurotrophic factor in fibromy-algia and in healthy controls, to investigate correlations between levels of nerve growth factor, brain-derived neurotrophic factor, and cytokines and clinical variables, and to investigate the effect of exercise on these levels. Subjects and methods: A total of 75 women with fibromyalgia participated in blood tests at baseline and after the 15-week intervention, and 25 healthy controls participated at baseline. Patients were randomized to a 15-week progressive resistance exercise intervention or a relaxation intervention. Results: Brain-derived neurotrophic factor level was significantly higher (p
Details
- Language :
- English
- ISSN :
- 16501977 and 16512081
- Volume :
- 51
- Issue :
- 10
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Rehabilitation Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5aef2fdc2b4a29b90524b2ee7c2bf4
- Document Type :
- article
- Full Text :
- https://doi.org/10.2340/16501977-2593