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Association of Lupus Anticoagulant status with Disease Course in SARS-CoV-2 (COVID-19) Infection

Authors :
Suhyeon Woo MD
Bohyun Kim MD, PhD
Nam Hun Heo MS
Min-sun Kim MD
Young Ahn Yoon MD
Young-Jin Choi MD, PhD
Source :
Clinical and Applied Thrombosis/Hemostasis, Vol 28 (2022)
Publication Year :
2022
Publisher :
SAGE Publishing, 2022.

Abstract

Background: We investigated the importance of lupus anticoagulant (LA) in patients with SARS-CoV-2. Methods: Medical records of 41 SARS-CoV-2 infected patients were reviewed. Patients were classified into two groups according to the frequency of positive LA test results: “LA (−)” and “LA (+) ≥1” (LA positive at least once). Statistical analysis was performed to determine the association between LA presence and change in LA test results and disease course according to both hospital days (HD) and days after diagnosis (DD). Results: The prevalence of LA was 51.2%. Averagely, the first change in LA test result occurred during DD 12-13 and between HD 9-10. The second change occurred on DD 15-16 and HD 13-14. The presence of LA was associated with severe disease ( P = .004) but was not associated with thrombotic complications or mortality. The change of results from negative to positive or vice versa or the frequency of the changes was not associated with disease severity, thrombotic complications, or mortality. Conclusions: LA positivity can be regarded as one of the findings suggesting more serious SARS-CoV-2 infection.

Details

Language :
English
ISSN :
19382723 and 10760296
Volume :
28
Database :
Directory of Open Access Journals
Journal :
Clinical and Applied Thrombosis/Hemostasis
Publication Type :
Academic Journal
Accession number :
edsdoj.5ae4a1ddc1854390a478042800b8e81d
Document Type :
article
Full Text :
https://doi.org/10.1177/10760296221127276