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Contributions of peroxisome proliferator-activated receptor β/δ to skin health and disease
- Source :
- Biomolecular Concepts, Vol 4, Iss 1, Pp 53-64 (2013)
- Publication Year :
- 2013
- Publisher :
- De Gruyter, 2013.
-
Abstract
- Among the three peroxisome proliferator-activated receptor (PPAR) transcription factors, PPARβ/δ is the isotype with the broadest expression pattern. In fact, the expression of PPARβ/δ is ubiquitous, albeit at levels that are tightly regulated. Herein, we reviewed its multiple functions in skin health and disease. PPARβ/δ has pro-differentiating effects in keratinocytes, regulates sebocyte differentiation, and promotes hair follicle growth in healthy skin. Furthermore, we reviewed novel insights into the roles of PPARβ/δ in skin wound healing, especially in inhibiting apoptosis and in modulating keratinocyte proliferation and migration. Therefore, PPARβ/δ represents a research target for the understanding and treatment of inflammatory skin diseases, such as psoriasis and acne vulgaris. In addition, PPARβ/δ is a tumor growth modifier. Epidemiological studies have established that tumor progression may be exacerbated by chronic low-grade inflammation, a condition promoting the production of the lipids that act as modulators of PPARβ/δ activity. The action of PPARβ/δ in skin cancer is ambivalent, which might be explained by this receptor’s putative highly context-specific behavior, which depends on a combination of factors ranging from receptor expression levels to co-regulator distribution, diversity and activity of the ligands produced, and other tissue-specific conditions. Given its diverse and crucial roles in many tissues and organs, PPARβ/δ will remain a major focus of future research.
Details
- Language :
- English
- ISSN :
- 18685021 and 1868503X
- Volume :
- 4
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Biomolecular Concepts
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5adae520a7d84ea7a0469b1574bf9dea
- Document Type :
- article
- Full Text :
- https://doi.org/10.1515/bmc-2012-0035