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PDCD1 Single Nucleotide Polymorphisms in Iranian Patients With Juvenile Idiopathic Arthritis
- Source :
- Acta Medica Iranica, Vol 55, Iss 11 (2018)
- Publication Year :
- 2018
- Publisher :
- Tehran University of Medical Sciences, 2018.
-
Abstract
- Juvenile idiopathic arthritis (JIA) is a clinically heterogeneous cluster of complex diseases, in which both the genetic and environmental factors seem to play a role in the development of the disease. The current study aims to assess the association of programmed cell death 1 (PDCD1, also called PD-1) gene variants with JIA vulnerability in Iranian population. In this case-control association study, we investigated a group of 50 Iranian patients with JIA in comparison with 202 healthy controls and evaluated the frequency of alleles, genotypes, and haplotypes of PDCD1 single-nucleotide polymorphisms (SNPs), comprising PD-1.1 G/A, PD-1.3 G/A and PD-1.9 C/T, using PCR-RFLP method. Both the allelic and genotype frequencies of PD-1.1, PD-1.3 and PD-1.9 were similar in two groups of patients and controls. Moreover, no significant difference was observed between the two groups of patients and controls for GGC (PD-1.1 G, PD-1.3 G, PD-1.9 C), GAC (PD-1.1 G, PD-1.3 A, PD-1.9 C), and AGT (PD-1.1 A, PD-1.3 G, PD-1.9 T) haplotypes. Our results did not show any association between PDCD1 SNPs and the development of JIA in Iranian population.
Details
- Language :
- English
- ISSN :
- 00446025 and 17359694
- Volume :
- 55
- Issue :
- 11
- Database :
- Directory of Open Access Journals
- Journal :
- Acta Medica Iranica
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5a66f7d1278c4f17be27aedb4124f171
- Document Type :
- article