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Expression of heat shock protein 70 in nasopharyngeal carcinomas: different expression patterns correlate with distinct clinical prognosis

Expression of heat shock protein 70 in nasopharyngeal carcinomas: different expression patterns correlate with distinct clinical prognosis

Authors :
Cai Man-Bo
Wang Xiao-Pai
Zhang Jia-Xing
Han Hui-Qiong
Liu Chao-Chun
Bei Jin-Xin
Peng Ruo-Jun
Liang Yi
Feng Qi-Sheng
Wang Hai-Yun
Chen Li-Zhen
Fu Sha
Kang Tiebang
Shao Jian-Yong
Zeng Yi-Xin
Source :
Journal of Translational Medicine, Vol 10, Iss 1, p 96 (2012)
Publication Year :
2012
Publisher :
BMC, 2012.

Abstract

Abstract Background Heat shock protein 70, a stress protein, has been implicated in tumor progression. However, its role in nasopharyngeal carcinoma (NPC) progression has not yet been clearly investigated. Methods Immunohistochemistry (IHC) was employed to examine the expression patterns of Hsp70, human leukocyte antigen –A (HLA-A) in NPC tissue samples. Results The expression of Hsp70 exhibited different spatial patterns among nuclear, membrane and cytoplasm in 507 NPC tumor tissues. Kaplan-Meier survival analysis demonstrated that different Hsp70 expression patterns are correlated with different patient outcomes. High membranal and cytoplasmic levels of Hsp70 predicted good survival of patients. In contrast, high nuclear abundance of Hsp70 correlated with poor survival. Moreover, the membranal and cytoplasmic levels of Hsp70 were positively correlated with levels of the MHC I molecule HLA-A. Conclusions Different Hsp70 expression patterns had distinct predictive values. The different spatial abundance of Hsp70 may imply its important role in NPC development and provide insight for the development of novel therapeutic strategies involving immunotherapy for NPC.

Details

Language :
English
ISSN :
14795876
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Translational Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.5a44e09c24184e6c8b3e902994b4cb42
Document Type :
article
Full Text :
https://doi.org/10.1186/1479-5876-10-96