Back to Search Start Over

Cellular Crosstalk in the Vascular Wall Microenvironment: The Role of Exosomes in Vascular Calcification

Authors :
Yun-Yun Wu
Su-Kang Shan
Xiao Lin
Feng Xu
Jia-Yu Zhong
Feng Wu
Jia-Yue Duan
Bei Guo
Fu-Xing-Zi Li
Yi Wang
Ming-Hui Zheng
Qiu-Shuang Xu
Li-Min Lei
Wen-Lu Ou-Yang
Ke-Xin Tang
Chang-Chun Li
Muhammad Hasnain Ehsan Ullah
Ling-Qing Yuan
Source :
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Publication Year :
2022
Publisher :
Frontiers Media S.A., 2022.

Abstract

Vascular calcification is prevalent in aging, diabetes, chronic kidney disease, cardiovascular disease, and certain genetic disorders. However, the pathogenesis of vascular calcification is not well-understood. It has been progressively recognized that vascular calcification depends on the bidirectional interactions between vascular cells and their microenvironment. Exosomes are an essential bridge to mediate crosstalk between cells and organisms, and thus they have attracted increased research attention in recent years. Accumulating evidence has indicated that exosomes play an important role in cardiovascular disease, especially in vascular calcification. In this review, we introduce vascular biology and focus on the crosstalk between the different vessel layers and how their interplay controls the process of vascular calcification.

Details

Language :
English
ISSN :
2297055X
Volume :
9
Database :
Directory of Open Access Journals
Journal :
Frontiers in Cardiovascular Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.5a3e62fb8614d2385a28833ff87d3dc
Document Type :
article
Full Text :
https://doi.org/10.3389/fcvm.2022.912358