Back to Search Start Over

Clinical Features and Outcomes of Pediatric MYH7‐Related Dilated Cardiomyopathy

Authors :
Fernando de Frutos
Juan Pablo Ochoa
Gregory Webster
Mark Jansen
Paloma Remior
Torsten B. Rasmussen
Maria Sabater‐Molina
Roberto Barriales‐Villa
Francesca Girolami
Sergi Cesar
M. Eugenia Fuentes‐Cañamero
Reyes Alvarez García‐Rovés
Karim Wahbi
Javier Limeres
Milos Kubanek
Martijn G. Slieker
Georgia Sarquella‐Brugada
Dominic J. Abrams
Dennis Dooijes
Fernando Domínguez
Pablo Garcia‐Pavia
Source :
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 21 (2024)
Publication Year :
2024
Publisher :
Wiley, 2024.

Abstract

Background Although genetic variants in MYH7 are the most frequent cause of pediatric genetic dilated cardiomyopathy (DCM), there are no studies available describing this entity. We sought to describe clinical features, analyze variant location, and explore predictors of bad prognosis in pediatric MYH7‐related DCM. Methods and Results We evaluated clinical records from 44 patients (24 men; median age at diagnosis, 0.54 [interquartile range, 0.01–10.8] years) with pathogenic/likely pathogenic variants in MYH7 diagnosed with DCM at pediatric age (

Details

Language :
English
ISSN :
20479980
Volume :
13
Issue :
21
Database :
Directory of Open Access Journals
Journal :
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Publication Type :
Academic Journal
Accession number :
edsdoj.59e75968bc6945bab7fc180c951c9b2d
Document Type :
article
Full Text :
https://doi.org/10.1161/JAHA.124.036208