Higher Mixed lineage Kinase Domain-like protein (MLKL) is associated with worst overall survival in adult-type diffuse glioma patients

Introduction Recently, the search for novel molecular markers in adult-type diffuse gliomas has grown substantially, yet with few novel breakthroughs. As the presence of a necrotic center is a differential diagnosis for more aggressive entities, we hypothesized that genes involved in necroptosis may play a role in tumor progression. Aim Given that MLKL is the executioner of the necroptotic pathway, we evaluated whether this gene would help to predict prognosis of adult gliomas patients. Methods We analyzed a publicly available retrospective cohort (n = 530) with Kaplan Meier survival analysis (pResults We determined that MLKL is an independent predictive prognostic marker for overall survival in these patients (HR: 2.56, p